Concepedia

Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia

Makoto Hamada, Tetsuo Takayama, Tsuyoshi Shibata, Akira Hiratate, Masato Takahashi, Miyoko Yashiro, Noriko Takayama, Lisa Okumura-Kitajima, Hiroko Koretsune, Hiromitsu Kajiyama,

Bioorganic & Medicinal Chemistry Letters · 2018 · 12 citations · 16 references

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References

16

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

, , +17

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

, , +16

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

Johannes Schödel, Spyros Oikonomopoulos, Jiannis Ragoussis et al. · Blood · 2011 · 734 citations

, , +7

Treating anemia early in renal failure patients slows the decline of renal function: A randomized controlled trial

Chariclia Gouva, Petros Nikolopoulos, John P. A. Ioannidis et al. · Kidney International · 2004 · 409 citations · Full text

, , +12

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

M.A. McDonough, Vivian Li, Emily Flashman et al. · Proceedings of the National Academy of Sciences · 2006 · 368 citations · Full text

, , +16