Miyoko Yashiro

Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group

Tomomichi Chonan, Daisuke Wakasugi, Daisuke Yamamoto et al. · Bioorganic & Medicinal Chemistry · 2011 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

(4-Piperidinyl)-piperazine: A new platform for acetyl-CoA carboxylase inhibitors

Tomomichi Chonan, Takahiro Oi, Daisuke Yamamoto et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 21 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors

Tomomichi Chonan, Hiroki Tanaka, Daisuke Yamamoto et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 20 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia

Makoto Hamada, Tetsuo Takayama, Tsuyoshi Shibata et al. · Bioorganic & Medicinal Chemistry Letters · 2018 · 12 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +6