Overexpression of SNX3 Decreases Amyloid-β Peptide Production by Reducing Internalization of Amyloid Precursor Protein

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

Edward H. Koo, Sharon L. Squazzo · Journal of Biological Chemistry · 1994 · 987 citations · Full text

Protein Secretion, Alzheimer's Disease, Signal Transduction +12

Endocytic Pathway Abnormalities Precede Amyloid β Deposition in Sporadic Alzheimer’s Disease and Down Syndrome

Anne M. Cataldo, Corrinne M. Peterhoff, Juan C. Troncoso et al. · American Journal Of Pathology · 2000 · 825 citations · Full text

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

John R. Cirrito, Jae-Eun Kang, Jiyeon Lee et al. · Neuron · 2008 · 647 citations · Full text

Synaptic Plasticity, Neurodegenerative Diseases, Molecular Neuroscience +11

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

Martin Harterink, Fillip Port, Magdalena J. Lorenowicz et al. · Nature Cell Biology · 2011 · 342 citations · Full text

Signal Transduction, Signaling Pathway, Cell Trafficking +10

SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P

Yue Xu, Heinz Hortsman, Li‐Fong Seet et al. · Nature Cell Biology · 2001 · 282 citations

Signal Transduction, Signaling Pathway, Molecular Regulation +9