Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines

Rapid Measurement of Intracellular Unbound Drug Concentrations

André Mateus, Pär Matsson, Per Artursson · Molecular Pharmaceutics · 2013 · 172 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +13

Species Independence in Brain Tissue Binding Using Brain Homogenates

Li Di, John P. Umland, George Chang et al. · Drug Metabolism and Disposition · 2011 · 161 citations

Medicine, Neuroscience, Pharmacology +10

Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia

Renata M. Oballa, Liette Belair, W. Cameron Black et al. · Journal of Medicinal Chemistry · 2011 · 142 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Impact of Nonspecific Binding to Microsomes and Phospholipid on the Inhibition of Cytochrome P4502D6: Implications for Relating in Vitro Inhibition Data to in Vivo Drug Interactions

Jeannine M. Margolis, R. Scott Obach · Drug Metabolism and Disposition · 2003 · 135 citations

Medicine, Biochemistry, Pharmacology +17

Plasma Protein Binding of Challenging Compounds

Keith Riccardi, Shannon Cawley, Phillip D. Yates et al. · Journal of Pharmaceutical Sciences · 2015 · 117 citations

Pharmacy, Biochemistry, Pharmacology +12