Concepedia

Rap1 Negatively Regulates the Hippo Pathway to Polarize Directional Protrusions in Collective Cell Migration

Yu-Chiuan Chang, Jhen-Wei Wu, Yi-Chi Hsieh, Tzu-Han Huang, Zih-Min Liao, Yi Huang, James A. Mondo, Denise J. Montell, Anna C.-C. Jang

Cell Reports · 2018 · 39 citations · 48 references

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Abstract

with the kinase domain of Hpo suppresses its activity, which releases Hpo signaling-mediated suppression of F-actin elongation, promoting cellular protrusions in collective cell migration.

References

48

The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP

Jianbin Huang, Shian Wu, Jose Barrera et al. · Cell · 2005 · 1.9K citations · Full text

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A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

Mariaceleste Aragona, Tito Panciera, Andrea Manfrin et al. · Cell · 2013 · 1.6K citations · Full text

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hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts

Shian Wu, Jianbin Huang, Jixin Dong et al. · Cell · 2003 · 1.1K citations · Full text

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The <i>Drosophila</i> mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells

Kei Ito, Wakae Awano, Kazumi Suzuki et al. · Development · 1997 · 780 citations

, , +10

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

Fisun Hamaratoǧlu, Maria Willecke, Madhuri Kango‐Singh et al. · Nature Cell Biology · 2005 · 772 citations

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