Caspase independent cleavages of TDP-43 generates 35kD fragment that cause apoptosis of breast cancer cells

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Manuela Neumann, Deepak M. Sampathu, Linda K. Kwong et al. · Science · 2006 · 6.5K citations

Tamoxifen for early breast cancer: an overview of the randomised trials

The Lancet · 1998 · 4.1K citations

Breast Oncology, Early Breast Cancer, Medicine +10

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Tetsuaki Arai, Masato Hasegawa, Haruhiko Akiyama et al. · Biochemical and Biophysical Research Communications · 2006 · 2.7K citations

Frontotemporal Lobar Degeneration, Amyotrophic Lateral Sclerosis, Ubiquitin-positive Tau-negative Inclusions +8

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

Alexandre Arcaro, Matthias P. Wymann · Biochemical Journal · 1993 · 1.1K citations · Full text

Immunology, Ptdinsp3 Production, Inflammation +17

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

Yong‐Jie Zhang, Ya-Fei Xu, Casey Cook et al. · Proceedings of the National Academy of Sciences · 2009 · 606 citations · Full text

Apoptosis, Cell Death, Molecular Biology +18