Chemical Communications · 2018 · 31 citations · 23 references
Life SciencesBiophysicsMolecular BiologyBiophysical ChemistryNeurodegenerationStructural BiologyAlzheimer DiseaseAmyloid FormationMagnetic Resonance SpectroscopyMolecular RotationNeurodegenerative DiseasesProtein AggregationAmyloid Aggregation KineticsAmyloid Beta AggregationAmyloid NucleationAmyloid Oligomer FormationAmyloidogenic ProteinsDynamic Nmr SpectroscopyReal-time Monitoring
monomers increases the rate of formation of aggregates, and that the increasing lag-time with peptide concentration suggests the formation of growth-incompetent species. EGCG's ability to shift off-pathway aggregation is also demonstrated.
23
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
Maj-Linda B. Selenica, Milene L. Brownlow, Jeffy P. Jimenez et al. · Neurodegenerative Diseases · 2012 · 10.4K citations · Full text