Spliceosome-Associated Protein 130 Exacerbates Alcohol-Induced Liver Injury by Inducing NLRP3 Inflammasome–Mediated IL-1β in Mice

Mouse model of chronic and binge ethanol feeding (the NIAAA model)

Adeline Bertola, Stephanie Mathews, Sung Hwan Ki et al. · Nature Protocols · 2013 · 1.2K citations · Full text

Energy Homeostasis, Binge Ethanol Feeding, Behavioral Neuroscience +14

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Hendrik Poeck, Michael Bscheider, Catherine Dostert et al. · Nature · 2009 · 899 citations

Inflammation, Antifungal Agent, Anti-fungal Host Defence +11

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

Eri Ishikawa, Tetsuaki Ishikawa, Yasu S. Morita et al. · The Journal of Experimental Medicine · 2009 · 760 citations · Full text

Mincle is an ITAM-coupled activating receptor that senses damaged cells

Sho Yamasaki, Eri Ishikawa, Machie Sakuma et al. · Nature Immunology · 2008 · 726 citations

Molecular Physiology, Signal Transduction, Itam-coupled Activating Receptor +9

Kupffer Cells Promote Hepatic Steatosis Via Interleukin-1β–Dependent Suppression of Peroxisome Proliferator-Activated Receptor α Activity

Rinke Stienstra, Fredy Z. Saudale, Caroline Duval et al. · Hepatology · 2009 · 441 citations