Concepedia

A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response

Niko Amin-Wetzel, Reuben A. Saunders, Maarten J. Kamphuis, Cláudia Rato, Heather P. Harding, David Ron

Cell · 2017 · 256 citations · 58 references

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Concepts

Abstract

to its default, dimeric, and active state. These observations establish BiP and its J domain co-chaperones as key regulators of the UPR.

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