Concepedia

A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies

Ume-Kulsoom Shah, Jefferson de Oliveira Mallia, Neenu Singh, Katherine E. Chapman, Shareen H. Doak, Gareth Jenkins

Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2017 · 95 citations · 15 references

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Concepts

References

15

Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

Jens M. Kelm, Nicholas Timmins, Catherine J. Brown et al. · Biotechnology and Bioengineering · 2003 · 916 citations

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A Simple Hanging Drop Cell Culture Protocol for Generation of 3D Spheroids

Ramsey A. Foty · Journal of Visualized Experiments · 2011 · 510 citations · Full text

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A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

Sreenivasa Ramaiahgari, Michiel W. den Braver, Bram Herpers et al. · Archives of Toxicology · 2014 · 358 citations

, , +13

Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes

Lei Guo, Stacey L. Dial, Leming Shi et al. · Drug Metabolism and Disposition · 2010 · 341 citations · Full text

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Modelling tissues in 3D: the next future of pharmaco-toxicology and food research?

Giovanna Mazzoleni, Diego Di Lorenzo, Nathalie Steimberg · Genes & Nutrition · 2008 · 247 citations · Full text

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