Concepedia

Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way

Jinyun Zhu, Kai Lü, Ning Zhang, Yun Zhao, Qunchao Ma, Jian Shen, Yinuo Lin, Pingping Xiang, Yaoliang Tang, Xinyang Hu,

Artificial Cells Nanomedicine and Biotechnology · 2017 · 262 citations · 25 references

DOIFull text

Open access

Concepts

Abstract

. In conclusion, hypoxic culture augments miR-210 and nSMase2 activities in MSCs and their secreted exosomes, and this is responsible at least in part for the enhanced cardioprotective actions of exosomes derived from hypoxia-treated cells.

References

25

Rab27a and Rab27b control different steps of the exosome secretion pathway

Matías Ostrowski, Nuno Carmo, Sophie Krumeich et al. · Nature Cell Biology · 2009 · 2.7K citations · Full text

, , +10

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

Ruenn Chai Lai, Fatih Arslan, May May Lee et al. · Stem Cell Research · 2010 · 2.2K citations

, , +10

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

Fatih Arslan, Ruenn Chai Lai, Mirjam B. Smeets et al. · Stem Cell Research · 2013 · 1.1K citations

, , +15

Hypoxic enhancement of exosome release by breast cancer cells

Hamish W. King, Michael Michael, Jonathan Gleadle · BMC Cancer · 2012 · 1.1K citations · Full text

, , +16

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

Pasquale Fasanaro, Yuri D’Alessandra, Valeria Di Stefano et al. · Journal of Biological Chemistry · 2008 · 909 citations · Full text

, , +17