Cardiac regeneration is the biological process and associated research field focused on the repair and replacement of damaged heart tissue, aiming to restore cardiac structure and function. It investigates the limited intrinsic regenerative capacity of the adult mammalian heart and explores therapeutic strategies, including cell-based approaches, gene therapy, and pharmacological interventions, to stimulate myocyte proliferation, replace fibrotic scar tissue with functional myocardium, and improve outcomes following injury such as myocardial infarction.