Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats - Concepedia

Concepedia

Publication | Open Access

Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats

DOI Full Paper Access

65

Citations

43

References

2017

Year

Mélanie Campana, Lara Bellini, Claude Rouch, Latif Rachdi, Nicolas Coant, Noémie Butin, Cécile L. Bandet, Erwann Philippe, Kelly Meneyrol, Nadim Kassis,

Molecular Metabolism

Abstract

Our results highlight a key role of hypothalamic de novo ceramide synthesis in central insulin resistance installation and glucose homeostasis dysregulation associated with obesity.

References

	Year	Citations

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