Concepedia

Ceramide Biosynthesis

Ceramide Biosynthesis is a metabolic pathway constituting the de novo synthesis of ceramides through the sequential acylation of serine and palmitoyl-CoA followed by N-acylation and reduction, distinguished from related lipid metabolic processes by its specific initiation of sphingolipid production in the endoplasmic reticulum.

2K

Publications

137K

Citations

8.6K

Authors

1.8K

Institutions

Publications per year

2017–2026

323

Parents

Publications

2K

The sphingomyelin cycle and the second messenger function of ceramide.

Yusuf A. Hannun · Journal of Biological Chemistry · 1994 · 1.3K citations · Full text

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Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance

William L. Holland, Joseph T. Brozinick, Liping Wang et al. · Cell Metabolism · 2007 · 1.2K citations · Full text

, , +14

Molecular machinery for non-vesicular trafficking of ceramide

Kentaro Hanada, Keigo Kumagai, Satoshi Yasuda et al. · Nature · 2003 · 1K citations

, , +14

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

William L. Holland, Russell Miller, Zhao V. Wang et al. · Nature Medicine · 2010 · 879 citations · Full text

, , +16

Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis

Jouni Vesa, Elina Hellsten, Linda A. Verkruyse et al. · Nature · 1995 · 740 citations

, , +13

1–5 of 2K

Authors

8.6K

  1. YA
    Yusuf A. Hannun

    Medical University of South Carolina, United States

    90 publications · 12.1K citations

    60

    h-index

  2. LM
    Lina M. Obeid

    Medical University of South Carolina, United States

    49 publications · 5.7K citations

    36

    h-index

  3. AH
    Anthony H. Futerman

    Weizmann Institute of Science, Israel

    48 publications · 5K citations

    34

    h-index

  4. JB
    Jacek Bielawski

    Medical University of South Carolina, United States

    37 publications · 3.5K citations

    31

    h-index

  5. AH
    Alfred H. Merrill

    Emory University, United States

    33 publications · 4.7K citations

    31

    h-index

1–5 of 8.6K

Institutions

1.8K

  1. Medical University of South Carolina

    Charleston, United States

    61 h-index

    488 publications

    41.4K citations

  2. Inserm

    Paris, France

    38 h-index

    320 publications

    24K citations

  3. Weizmann Institute of Science

    Rehovot, Israel

    35 h-index

    164 publications

    20.1K citations

  4. University of Michigan

    Ann Arbor, United States

    32 h-index

    124 publications

    10.1K citations

  5. University of Bonn

    Bonn, Germany

    29 h-index

    183 publications

    18.2K citations

  6. Duke Medical Center

    Durham, United States

    27 h-index

    87 publications

    16.3K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    27 h-index

    166 publications

    9.3K citations

  8. Ralph H. Johnson VA Medical Center

    Charleston, United States

    26 h-index

    56 publications

    5.8K citations

1–8 of 1.8K

Venues

  1. Journal of Biological Chemistry

    JBC · 303 publications · 38.1K citations

    116

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  2. Journal of Lipid Research

    JLR · 107 publications · 5.7K citations

    47

    h-index

  3. Biochemical Journal

    BJ · 56 publications · 4K citations

    37

    h-index

  4. PubMed

    Repository · 52 publications · 2.6K citations

    30

    h-index

  5. The FASEB Journal

    27 publications · 2.3K citations

    25

    h-index

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