William L. Holland

Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance

William L. Holland, Joseph T. Brozinick, Liping Wang et al. · Cell Metabolism · 2007 · 1.2K citations · Full text

Obesity, Metabolic Syndrome, Biochemistry +11

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

William L. Holland, Russell Miller, Zhao V. Wang et al. · Nature Medicine · 2010 · 871 citations · Full text

Molecular Physiology, Signal Transduction, Biochemistry +11

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

Gregory Gaich, Jenny Y. Chien, Haoda Fu et al. · Cell Metabolism · 2013 · 867 citations · Full text

Obesity, Metabolic Syndrome, Health Sciences +10

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

William L. Holland, Benjamin T. Bikman, Liping Wang et al. · Journal of Clinical Investigation · 2011 · 676 citations · Full text

Immunology, Tlr4 Recognition, Innate Immunity +20

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

William L. Holland, Andrew C. Adams, Joseph T. Brozinick et al. · Cell Metabolism · 2013 · 522 citations · Full text

Obesity, Metabolic Syndrome, Energy Homeostasis +11