Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance

William L. Holland, Joseph T. Brozinick, Liping Wang, +12

Cell Metabolism

ObesityMetabolic SyndromeBiochemistryMedicineInsulin Management +9

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

William L. Holland, Benjamin T. Bikman, Liping Wang, +10

Journal of Clinical Investigation

ImmunologyTlr4 RecognitionInnate ImmunityInsulin SignalingInflammation +18

A Role for Ceramide, but Not Diacylglycerol, in the Antagonism of Insulin Signal Transduction by Saturated Fatty Acids

Jose A. Chavez, Trina A. Knotts, Liping Wang, +4

Journal of Biological Chemistry

A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

Megan N. Roberts, Marita A. Wallace, Alexey Tomilov, +17

Cell Metabolism

Lifespan ExtensionNutritionAgingLongevityPhysiology +6

Acylcarnitines activate proinflammatory signaling pathways

Jennifer M. Rutkowsky, Trina A. Knotts, Kikumi D. Ono‐Moore, +6

American Journal of Physiology-Endocrinology and Metabolism

The Nuclear Corepressors NCoR and SMRT Are Key Regulators of Both Ligand- and 8-Bromo-Cyclic AMP-Dependent Transcriptional Activity of the Human Progesterone Receptor

Brandee Wagner, John D. Norris, Trina A. Knotts, +2

Molecular and Cellular Biology

Both Ligand-GynecologyHuman Progesterone ReceptorTranscriptional RegulationHormone Receptor +14

Acylcarnitines: potential implications for skeletal muscle insulin resistance

Céline Aguer, Colin S. McCoin, Trina A. Knotts, +7

The FASEB Journal

Insulin ResistanceMetabolic SyndromeBiochemistrySkeletal MusclePotential Implications +11

Increased P85α Is a Potent Negative Regulator of Skeletal Muscle Insulin Signaling and Induces in Vivo Insulin Resistance Associated with Growth Hormone Excess

Linda A. Barbour, Shaikh Mizanoor Rahman, Inga Gurevich, +12

Journal of Biological Chemistry

Growth Hormone ExcessPotent Negative RegulatorInsulin SignalingMetabolic SyndromeSkeletal Muscle +17

Lipid Mediators of Insulin Resistance

William L. Holland, Trina A. Knotts, Jose A. Chavez, +3

Nutrition Reviews

Myelin as a regulator of development of the microbiota-gut-brain axis

Ciara E. Keogh, Danielle Kim, Matteo M. Pusceddu, +8

Brain Behavior and Immunity

DysbiosisBrain DevelopmentGut MicrobiologyGut-organ AxisIntestinal Microbiota +14