Concepedia

An in silico approach to determine challenges in the bioavailability of ciprofloxacin, a poorly soluble weak base with borderline solubility and permeability characteristics

Simone Hansmann, Yoshihiro Miyaji, Jennifer Dressman

European Journal of Pharmaceutics and Biopharmaceutics · 2017 · 35 citations · 32 references

DOI

Concepts

References

32

Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

Trudy Rodgers, Malcolm Rowland · Journal of Pharmaceutical Sciences · 2006 · 940 citations

, , +11

Physiologically Based Pharmacokinetic Modeling 1: Predicting the Tissue Distribution of Moderate-to-Strong Bases

Trudy Rodgers, David E. Leahy, Malcolm Rowland · Journal of Pharmaceutical Sciences · 2005 · 774 citations

, , +13

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data

Kaoxiang Sun · Chinese New Drugs Journal · 2005 · 764 citations

, , +14

Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update

Ekarat Jantratid, Niels Janssen, Christos Reppas et al. · Pharmaceutical Research · 2008 · 745 citations

, , +14

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

R. Scott Obach, James G. Baxter, Theodore E. Liston et al. · PubMed · 1997 · 638 citations

, , +14