Concepedia

Solubility-permeability Relationship

The Solubility-Permeability Relationship is a theoretical construct in pharmaceutical sciences that describes the interdependent balance between a drug's aqueous solubility and its membrane permeability, governing its overall absorption potential in vivo.

266

Publications

29.6K

Citations

928

Authors

317

Institutions

Publications per year

2017–2026

75

Parents

Publications

266

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

, , +16

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 2012 · 3.7K citations

, , +16

A Provisional Biopharmaceutical Classification of the Top 200 Oral Drug Products in the United States, Great Britain, Spain, and Japan

Toshihide Takagi, Chandrasekharan Ramachandran, Marival Bermejo et al. · Molecular Pharmaceutics · 2006 · 597 citations

, , +17

Enhanced oral paclitaxel absorption with vitamin E-TPGS: Effect on solubility and permeability in vitro, in situ and in vivo

Manthena V. S. Varma, Ramesh Panchagnula · European Journal of Pharmaceutical Sciences · 2005 · 360 citations

, , +12

Solubility and transport phenomena in perfluorochemicals relevant to blood substitution and other biomedical applications

Jean G. Riess, Maurice Blanc · Pure and Applied Chemistry · 1982 · 284 citations · Full text

, , +9

1–5 of 266

Authors

928

  1. AD
    Arik Dahan

    Ben-Gurion University of the Negev, Israel

    21 publications · 1.8K citations

    21

    h-index

  2. AB
    Avital Beig

    Ben-Gurion University of the Negev, Israel

    13 publications · 1.2K citations

    13

    h-index

  3. JM
    Jonathan M. Miller

    Ben-Gurion University of the Negev, Israel

    12 publications · 1.3K citations

    12

    h-index

  4. MB
    Martin Brandl

    University of Southern Denmark, Denmark

    7 publications · 540 citations

    7

    h-index

  5. GF
    Gert Fricker

    Heidelberg University, Germany

    6 publications · 471 citations

    6

    h-index

1–5 of 928

Institutions

317

  1. Ben-Gurion University of the Negev

    Beersheba, Israel

    20 h-index

    57 publications

    4.1K citations

  2. University of Southern Denmark

    Odense, Denmark

    9 h-index

    24 publications

    1.4K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    20 publications

    1.2K citations

  4. University of Michigan

    Ann Arbor, United States

    7 h-index

    23 publications

    6.1K citations

  5. Heidelberg University

    Heidelberg, Germany

    6 h-index

    13 publications

    937 citations

  6. Uppsala University

    Uppsala, Sweden

    6 h-index

    27 publications

    4.1K citations

  7. AbbVie (United States)

    North Chicago, United States

    6 h-index

    14 publications

    834 citations

  8. Rutgers, The State University of New Jersey

    New Brunswick, United States

    5 h-index

    11 publications

    563 citations

1–8 of 317

Venues

  1. European Journal of Pharmaceutical Sciences

    21 publications · 1.8K citations

    18

    h-index

  2. Journal of Pharmaceutical Sciences

    19 publications · 1.2K citations

    17

    h-index

  3. International Journal of Pharmaceutics

    18 publications · 1K citations

    16

    h-index

  4. Molecular Pharmaceutics

    16 publications · 2K citations

    15

    h-index

  5. European Journal of Pharmaceutics and Biopharmaceutics

    EJPB · 14 publications · 1K citations

    13

    h-index

1–5