Bcl-2 inhibitor uploaded upconversion nanophotosensitizers to overcome the photodynamic therapy resistance of cancer through adjuvant intervention strategy

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

Xuesong Liu, Caryn Naekyung Kim, Jie Yang et al. · Cell · 1996 · 5.2K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

David M. Hockenbery, Zoltán N. Oltvai, Xiao-Ming Yin et al. · Cell · 1993 · 3.4K citations

Life Sciences, Biochemistry, Cell Biology +12

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Tilman Oltersdorf, Steven W. Elmore, Alexander R. Shoemaker et al. · Nature · 2005 · 3.4K citations

Medicine, Molecular Biology, Oncology +14

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

Naoufal Zamzami, Philippe Marchetti, Maria Castedo et al. · The Journal of Experimental Medicine · 1995 · 1.6K citations · Full text

Life Sciences, Biochemistry, Cell Biology +12

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Mark F. van Delft, Andrew H. Wei, Kylie D. Mason et al. · Cancer Cell · 2006 · 1.2K citations · Full text

Life Sciences, Cell Biology, Pharmacology +10