Concepedia

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors

Marta Carrara, Anna Sigurdardottir, Anne Bertolotti

Nature Structural & Molecular Biology · 2017 · 95 citations · 26 references

DOI

Concepts

References

26

A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

Michael Boyce, Kevin F. Bryant, Céline Jousse et al. · Science · 2005 · 1.4K citations

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Feedback Inhibition of the Unfolded Protein Response by <i>GADD34</i>-Mediated Dephosphorylation of eIF2α

Isabel Novoa, Huiqing Zeng, Heather P. Harding et al. · The Journal of Cell Biology · 2001 · 1.4K citations · Full text

, , +17

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 929 citations

, , +16

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

Pavel Tsaytler, Heather P. Harding, David Ron et al. · Science · 2011 · 526 citations

, , +16

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

Indrajit Das, Agnieszka Krzyżosiak, Kim Schneider et al. · Science · 2015 · 448 citations

, , +16