Treg-protected donor lymphocyte infusions: a new tool to address the graft-versus-leukemia effect in the absence of graft-versus-host disease in patients relapsed after HSCT

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter et al. · Nature Immunology · 2010 · 5.8K citations · Full text

Life Sciences, Cell Biology, Immunology +17

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Shimon Sakaguchi, N Sakaguchi, M Asano et al. · The Journal of Immunology · 1995 · 5.5K citations

Life Sciences, Immunology, Pathology +17

Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts

P L Weiden, Nancy Flournoy, E D Thomas et al. · New England Journal of Medicine · 1979 · 1.5K citations

Medicine, Hematology, Immunology +13

CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

Matthias Edinger, Petra Hoffmann, Joerg Ermann et al. · Nature Medicine · 2003 · 1.3K citations

Life Sciences, Immunology, Oncology +17

Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation

Petra Hoffmann, Joerg Ermann, Matthias Edinger et al. · The Journal of Experimental Medicine · 2002 · 1.1K citations · Full text

Life Sciences, Cell Biology, Immunology +15