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Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach

Medicinal ChemistryBiochemistryPain MedicineMedicineNatural SciencesScaffold Hopping ApproachMechanism Of ActionPharmacological AgentNeuropharmacologyMolecular PainPharmacotherapyAnalgesic ActivityPharmacologyAnalgesicsDrug DiscoveryPain Research