A Formulation Development Approach to Identify and Select Stable Ultra–High-Concentration Monoclonal Antibody Formulations With Reduced Viscosities

Challenges in the development of high protein concentration formulations

Zahra Shahrokh, Jun 军 Liu 刘 · Journal of Pharmaceutical Sciences · 2004 · 879 citations

Pharmacy, Pharmaceutics, Pharmacokinetics +12

Reversible Self-Association Increases the Viscosity of a Concentrated Monoclonal Antibody in Aqueous Solution

Jun Liu, Mary D.H. Nguyen, James D. Andya et al. · Journal of Pharmaceutical Sciences · 2005 · 439 citations

Pharmacy, Biochemistry, Immunology +15

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

Brian D. Connolly, Chris Petry, Sandeep Yadav et al. · Biophysical Journal · 2012 · 341 citations · Full text

Engineering, Biochemistry, Immunology +11

Reversible Self-Association of a Concentrated Monoclonal Antibody Solution Mediated by Fab–Fab Interaction That Impacts Solution Viscosity

Sonoko Kanai, Jun Liu, Thomas W. Patapoff et al. · Journal of Pharmaceutical Sciences · 2008 · 305 citations

Pharmacy, Biochemistry, Molecular Biology +17

Trends in Active Pharmaceutical Ingredient Salt Selection based on Analysis of the Orange Book Database

G. Steffen Paulekuhn, Jennifer Dressman, Christoph Saal · Journal of Medicinal Chemistry · 2007 · 297 citations

Pharmacy, Chemistry, Medicinal Chemistry +14