Concepedia

High-concentration Formulations

High-Concentration Formulations is a specialized category of antibody formulation characterized by significantly elevated protein concentrations, typically exceeding 100 mg/mL, designed to enable subcutaneous administration and improve patient convenience while addressing challenges related to viscosity, stability, and manufacturability.

128

Publications

5.6K

Citations

673

Authors

187

Institutions

Publications per year

2017–2026

62

Parents

Publications

128

Challenges in the development of high protein concentration formulations

Zahra Shahrokh, Jun 军 Liu 刘 · Journal of Pharmaceutical Sciences · 2004 · 879 citations

, , +12

Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodies

Reed J. Harris, Steven J. Shire, Charles Winter · Drug Development Research · 2004 · 197 citations

, , +17

Understanding and Modulating Opalescence and Viscosity in a Monoclonal Antibody Formulation

Branden A. Salinas, Hasige A. Sathish, Steven M. Bishop et al. · Journal of Pharmaceutical Sciences · 2009 · 191 citations · Full text

, , +14

High-concentration protein formulations: How high is high?

Patrick Garidel, Alexander Kühn, Lars V. Schäfer et al. · European Journal of Pharmaceutics and Biopharmaceutics · 2017 · 188 citations

, , +8

Crystalline monoclonal antibodies for subcutaneous delivery

Mark X. Yang, Bhami C. Shenoy, Matthew Disttler et al. · Proceedings of the National Academy of Sciences · 2003 · 167 citations · Full text

, , +17

1–5 of 128

Authors

673

  1. KS
    Kentaro Shiraki

    University of Tsukuba, Japan

    7 publications · 261 citations

    7

    h-index

  2. PG
    Patrick Garidel

    Martin Luther University Halle-Wittenberg, Germany

    6 publications · 373 citations

    6

    h-index

  3. YM
    Yuh‐Fun Maa

    Roche (Switzerland), Switzerland

    5 publications · 198 citations

    5

    h-index

  4. TW
    Theodore W. Randolph

    University of Colorado Boulder, United States

    5 publications · 347 citations

    5

    h-index

  5. OB
    O. B. Stauch

    Roche (Switzerland), Switzerland

    4 publications · 128 citations

    4

    h-index

1–5 of 673

Institutions

187

  1. Amgen (United States)

    Thousand Oaks, United States

    8 h-index

    30 publications

    821 citations

  2. Roche (Switzerland)

    Basel, Switzerland

    8 h-index

    15 publications

    640 citations

  3. Pfizer (United States)

    New York, United States

    8 h-index

    40 publications

    2.1K citations

  4. University of Tsukuba

    Tsukuba, Japan

    7 h-index

    20 publications

    783 citations

  5. Boehringer Ingelheim (Germany)

    Ingelheim, Germany

    6 h-index

    19 publications

    1.2K citations

  6. Merck KGaA, Darmstadt (Germany)

    Darmstadt, Germany

    5 h-index

    13 publications

    518 citations

  7. Terumo (Japan)

    Tokyo, Japan

    5 h-index

    12 publications

    296 citations

  8. University of Colorado Boulder

    Boulder, United States

    5 h-index

    13 publications

    1.1K citations

1–8 of 187

Venues

  1. Journal of Pharmaceutical Sciences

    30 publications · 1.4K citations

    23

    h-index

  2. mAbs

    10 publications · 365 citations

    10

    h-index

  3. Molecular Pharmaceutics

    9 publications · 427 citations

    9

    h-index

  4. European Journal of Pharmaceutics and Biopharmaceutics

    EJPB · 7 publications · 476 citations

    7

    h-index

  5. Pharmaceutical Research

    5 publications · 351 citations

    5

    h-index

1–5