The Influence of Donor and Reservoir Additives on Caco-2 Permeability and Secretory Transport of HIV Protease Inhibitors and Other Lipophilic Compounds

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

Per Artursson, Johan Karlsson · Biochemical and Biophysical Research Communications · 1991 · 1.9K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Richard B. Kim, Martin F. Fromm, Christoph Wandel et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors

Patrick Y. S. Lam, Prabhakar K. Jadhav, Charles J. Eyermann et al. · Science · 1994 · 836 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

HIV-1 Protease Inhibitors Are Substrates for the<i>MDR</i>1 Multidrug Transporter

Caroline Lee, Michael M. Gottesman, Carol Cardarelli et al. · Biochemistry · 1998 · 482 citations

Medicine, Pharmacokinetics, Pharmacology +17

Absorption Potential: Estimating the Fraction Absorbed for Orally Administered Compounds

Jennifer Dressman, Gordon L. Amidon, David Fleisher · Journal of Pharmaceutical Sciences · 1985 · 223 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +16