Concepedia

Membrane Permeability Optimization

Membrane Permeability Optimization is a strategic methodology in medicinal chemistry aimed at enhancing the passive diffusion of antiviral prodrugs across biological membranes by systematically modulating molecular properties such as lipophilicity, polarity, and hydrogen-bonding capacity to achieve improved bioavailability and tissue penetration.

111

Publications

5.7K

Citations

677

Authors

216

Institutions

Publications per year

2017–2026

57

Parents

Publications

111

Shelf-Stable Electrophilic Reagents for Trifluoromethylthiolation

Xinxin Shao, Chunfa Xu, Long Lü et al. · Accounts of Chemical Research · 2015 · 407 citations

, , +13

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

Alexander Alex, David S. Millan, Manuel Pérez et al. · MedChemComm · 2011 · 323 citations

, , +17

Pharmaceutical applications of cyclodextrins: effects on drug permeation through biological membranes

Marcus E. Brewster · Journal of Pharmacy and Pharmacology · 2011 · 278 citations · Full text

, , +16

High Throughput Prediction of Oral Absorption: Improvement of the Composition of the Lipid Solution Used in Parallel Artificial Membrane Permeation Assay

Kiyohiko Sugano, Hirokazu Hamada, Minoru Machida et al. · SLAS DISCOVERY · 2001 · 201 citations · Full text

, , +17

Accurate de novo design of membrane-traversing macrocycles

Gaurav Bhardwaj, Jacob O’Connor, Stephen Rettie et al. · Cell · 2022 · 170 citations · Full text

, , +17

1–5 of 111

Authors

677

  1. MM
    Minoru Machida

    Hokkaido University, Japan

    2 publications · 212 citations

    2

    h-index

  2. WL
    Wen‐Yong Lou

    South China University of Technology, China

    2 publications · 94 citations

    2

    h-index

  3. RS
    R. Scott Lokey

    University of California, Santa Cruz, United States

    2 publications · 166 citations

    2

    h-index

  4. MZ
    Min‐Hua Zong

    South China University of Technology, China

    2 publications · 94 citations

    2

    h-index

  5. WC
    Wesley C. Van Voorhis

    University of Washington, United States

    2 publications · 214 citations

    2

    h-index

1–5 of 677

Institutions

216

  1. The University of Queensland

    Brisbane, Australia

    4 h-index

    10 publications

    551 citations

  2. October 6 University

    Giza, Egypt

    3 h-index

    4 publications

    129 citations

  3. Tianjin University

    Tianjin, China

    3 h-index

    10 publications

    143 citations

  4. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    15 publications

    2.3K citations

  5. South China University of Technology

    Guangzhou, China

    3 h-index

    10 publications

    686 citations

  6. University of Michigan

    Ann Arbor, United States

    3 h-index

    20 publications

    528 citations

  7. Cairo University

    Giza, Egypt

    3 h-index

    11 publications

    373 citations

  8. National Cancer Institute

    Bethesda, United States

    2 h-index

    6 publications

    528 citations

1–8 of 216

Venues

  1. Journal of Medicinal Chemistry

    10 publications · 629 citations

    10

    h-index

  2. Journal of Membrane Science

    6 publications · 212 citations

    6

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    4 publications · 80 citations

    4

    h-index

  4. International Journal of Pharmaceutics

    4 publications · 183 citations

    4

    h-index

  5. Bioorganic & Medicinal Chemistry

    4 publications · 190 citations

    4

    h-index

1–5