Concepedia

Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus

Hideki Hirose, Takeshi Yamasaki, Masaki Ogino, Ryo Mizojiri, Yumiko Tamura-Okano, Hiroaki Yashiro, Yo Muraki, Yoshihide Nakano, Jun Sugama, Akito Hata,

Bioorganic & Medicinal Chemistry · 2017 · 28 citations · 21 references

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21

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Frank Lovering, Jack Bikker, Christine Humblet · Journal of Medicinal Chemistry · 2009 · 4.4K citations

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Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

Paul Brazeau, Wylie Vale, Roger Burgus et al. · Science · 1973 · 3.5K citations

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A structural basis for drug-induced long QT syndrome

John S. Mitcheson, Jun Chen, Monica Lin et al. · Proceedings of the National Academy of Sciences · 2000 · 937 citations

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Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

Astrid C. Hauge-Evans, Aileen King, Danielle Carmignac et al. · Diabetes · 2008 · 326 citations · Full text

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Somatostatin Receptor Subtype 5 Regulates Insulin Secretion and Glucose Homeostasis

Mathias Z. Strowski, Martin Köhler, Howard Y. Chen et al. · Molecular Endocrinology · 2003 · 129 citations · Full text

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