Characterization of a novel ghrelin cell reporter mouse

Ichiro Sakata, Yoshihide Nakano, Sherri Osborne‐Lawrence, +9

Regulatory Peptides

Knockout MouseMolecular PhysiologyCellular BiochemistryMedicineCell Biology +3

Novel Benzodioxan Derivative, 5-{3-[((2S)-1,4-Benzodioxan-2-ylmethyl)amino]propoxy}-l,3-benzodioxole HC1 (MKC-242), with a Highly Potent and Selective Agonist Activity at Rat Central Serotonin1A Receptors

Toshio Matsuda, Takashi Yoshikawa, Makoto Suzuki, +10

The Japanese Journal of Pharmacology

Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors

Makoto Kamata, Asato Kina, Michiko Tawada, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentSymmetrical ApproachPharmacotherapy +3

Melanin-Concentrating Hormone Receptor 1 Antagonists. Synthesis and Structure–Activity Relationships of Novel 3-(Aminomethyl)quinolines

Makoto Kamata, Toshiro Yamashita, Toshihiro Imaeda, +17

Journal of Medicinal Chemistry

Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus

Hideki Hirose, Takeshi Yamasaki, Masaki Ogino, +11

Bioorganic & Medicinal Chemistry

MedicineType 2Mechanism Of ActionPharmacological AgentPharmacotherapy +3

Gonadectomy changes the pituitaiy-adrenocortical response in mice to S-HT1A receptor agonists

Toshio Matsuda, Yoshihide Nakano, Tomoyuki Kanda, +2

European Journal of Pharmacology

Pituitaiy-adrenocortical ResponseEndocrine MechanismHormonal ReceptorPhysiologyNeuroendocrine Mechanism +6

Synthesis, Structure–Activity Relationship, and Pharmacological Studies of Novel Melanin-Concentrating Hormone Receptor 1 Antagonists 3-Aminomethylquinolines: Reducing Human Ether-a-go-go-Related Gene (hERG) Associated Liabilities

Shizuo Kasai, Makoto Kamata, Shinichi Masada, +17

Journal of Medicinal Chemistry

Structure–activity RelationshipFood IntakePharmacotherapyExperimental PharmacologyPharmaceutical Chemistry +15

Identification and Characterization of a New Series of Ghrelin O-Acyl Transferase Inhibitors

Mariko Yoneyama-Hirozane, Kohei Deguchi, Takeshi Hirakawa, +9

SLAS DISCOVERY

Hit CompoundsMedicinal ChemistryBiosynthesisBioorganic ChemistryPharmaceutical Science +13

Sex difference for tolerance of 5-HT1A receptor-mediated temperature and corticosterone responses in mice

Yoshihide Nakano, Toshio Matsuda, Kazuhiro Takuma, +2

European Journal of Pharmacology

5-Ht1a Receptor-mediated TemperatureEndocrine MechanismBehavioral NeuroscienceMedicineGenetics +6

Melanin-concentrating hormone receptor 1 antagonists: Synthesis, structure–activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives

Shizuo Kasai, Masahiro Kamaura, Makoto Kamata, +11

Bioorganic & Medicinal Chemistry

Structure–activity RelationshipMolecular PharmacologyMedicinal Chemistry2,3,4,5-Tetrahydro-1h-3-benzazepine DerivativesBiochemistry +10