Concepedia

Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy

Zigao Yuan, Shaopeng Chen, Qinsheng Sun, Ning Wang, Dan Li, Shuangshuang Miao, Chunmei Gao, Chunyan Tan, Yuyang Jiang

Bioorganic & Medicinal Chemistry · 2017 · 87 citations · 27 references

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27

Gamma-H2AX - a novel biomarker for DNA double-strand breaks.

Linda J Kuo, Li‐Xi Yang · PubMed · 2008 · 1.2K citations

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Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

Kyle V. Butler, Jay H. Kalin, Camille Brochier et al. · Journal of the American Chemical Society · 2010 · 772 citations · Full text

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4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2<i>H</i>-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

Keith Menear, Claire Adcock, Robert Boulter et al. · Journal of Medicinal Chemistry · 2008 · 586 citations · Full text

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Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

Benjamin Lauffer, Robert Mintzer, Rina Fong et al. · Journal of Biological Chemistry · 2013 · 412 citations · Full text

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Pharmaceutical profiling in drug discovery

Edward H. Kerns · Drug Discovery Today · 2003 · 283 citations

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