Metformin ameliorates hypoxia/reoxygenation-induced cardiomyocyte apoptosis based on the SIRT3 signaling pathway

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

Xingxing Kong, Rui Wang, Yuan Xue et al. · PLoS ONE · 2010 · 712 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria

Patrick Onyango, Ivana Celic, J. Michael McCaffery et al. · Proceedings of the National Academy of Sciences · 2002 · 580 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

Orsolya M Palacios, Juan J. Carmona, Shaday Michán et al. · Aging · 2009 · 480 citations · Full text

Life Sciences, Biochemistry, Physiology +17

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

Ghorbangol Ashabi, Leila Khalaj, Fariba Khodagholi et al. · Metabolic Brain Disease · 2014 · 255 citations

Life Sciences, Neuroscience, Pharmacology +16

Metformin Protects Cardiomyocyte from Doxorubicin Induced Cytotoxicity through an AMP-Activated Protein Kinase Dependent Signaling Pathway: An In Vitro Study

Laura C. Kobashigawa, Yan Xu, James F. Padbury et al. · PLoS ONE · 2014 · 132 citations · Full text

Medicine, Oncology, Pharmacology +17