Concepedia

Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction

Samer Tohme, Hamza O. Yazdani, Yao Liu, Patricia Loughran, Dirk J. van der Windt, Hai Huang, Richard L. Simmons, Sruti Shiva, Sheng Tai, Allan Tsung

Hepatology · 2017 · 136 citations · 20 references

DOI Full text

Open access

Abstract

Taken together, our findings suggest that during hypoxia HMGB1 up-regulates mitochondrial biogenesis in HCC cancer cells, promoting tumor survival and proliferation. (Hepatology 2017;66:182-197).

References

20

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Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2016 · 16.1K citations · Full text

On the Origin of Cancer Cells

Otto Warbürg · Science · 1956 · 13.1K citations

Human Cell, Months1,079total Citations9,249last 6, Engineering +13

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Nicholas McGranahan, Andrew J.S. Furness, Rachel Rosenthal et al. · Science · 2016 · 3K citations

T-regulatory Cell, Immunology, Pathology +20

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Sibylle Jäger, Christoph Handschin, Julie St‐Pierre et al. · Proceedings of the National Academy of Sciences · 2007 · 2.4K citations · Full text

Muscle Function, Direct Phosphorylation, Metabolic Remodeling +21

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

Valerie S. LeBleu, Joyce T. O’Connell, Karina N. Gonzalez Herrera et al. · Nature Cell Biology · 2014 · 1.4K citations · Full text