Klotho ameliorates cyclosporine A–induced nephropathy via PDLIM2/NF-kB p65 signaling pathway

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations

Life Sciences, Genetics, Molecular Genetics +12

Suppression of Aging in Mice by the Hormone Klotho

Hiroshi Kurosu, Masaya Yamamoto, Jeremy D. Clark et al. · Science · 2005 · 1.9K citations · Full text

Education, Endocrinology, Genetics +17

Severely Reduced Production of Klotho in Human Chronic Renal Failure Kidney

Noritoshi Koh, Toshihiko Fujimori, Shuhei Nishiguchi et al. · Biochemical and Biophysical Research Communications · 2001 · 494 citations

Medicine, Biochemistry, Nephrology +9

Off-target effects by siRNA can induce toxic phenotype

Yuriy Fedorov, Emily M. Anderson, Amanda Birmingham et al. · RNA · 2006 · 490 citations · Full text

Life Sciences, Genetics, Molecular Biology +15

PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit

Takashi Tanaka, Michael J. Grusby, Tsuneyasu Kaisho · Nature Immunology · 2007 · 335 citations

Life Sciences, Cell Biology, Molecular Biology +10