Cell Reports · 2017 · 93 citations · 62 references
MedicineGeneticsOncologyGene ExpressionMolecular OncologyTranscriptional RegulationCancer EpigeneticsCancer GenomicsCancer TranscriptomicsEnhancer FunctionEpigenetic Regulation In CancerTumor Suppressor GenesAnti-proliferative SignalingBreast Cancer EpigeneticsCell Type-specific Enhancer ActivityEnhancer-driven Transcriptional RegulationEnhancer-mediated ExpressionEnhancersOncogenic TransformationPromoter Enhancer Elements
cells. In primary mammary cells, MEN1 exerts an anti-proliferative function by regulating a distinct expression signature. Our findings clarify the cell-type-specific functions of MEN1 and inform the development of menin-directed treatments for breast cancer.
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An integrated encyclopedia of DNA elements in the human genome
Comprehensive molecular portraits of human breast tumours
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Jordi Barretina, Giordano Caponigro, Nicolas Stransky et al. · Nature · 2012 · 8.5K citations
Medicine, Oncology, Pharmacology +15
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Christina Curtis, Sohrab P. Shah, Suet‐Feung Chin et al. · Nature · 2012 · 6.4K citations · Full text
Life Sciences, Genetics, Oncology +14