Concepedia

A recurrent endometrial stromal sarcoma harbors the novel fusion JAZF1-BCORL1

Allison Allen, Siraj M. Ali, Kyle Gowen, Julia A. Elvin, Tanja Pejović

Gynecologic Oncology Reports · 2017 · 51 citations · 9 references

DOIFull text

Open access

Concepts

Abstract

•Genomic alterations may improve diagnostic certainty and subsequent treatment of endometrial stromal sarcoma.•Novel JAZF1-BCORL1 mutation was identified.•Targeted therapeutics to down-stream targets may improve survival benefit in these patients.

References

9

Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing

Garrett M. Frampton, Alex Fichtenholtz, Geoff Otto et al. · Nature Biotechnology · 2013 · 2.2K citations · Full text

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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

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PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

Eline Beert, Éric Pasmant, Armelle Luscan et al. · Nature · 2014 · 469 citations

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Phase I, Dose-Escalation Trial of the Oral Cyclin-Dependent Kinase 4/6 Inhibitor PD 0332991, Administered Using a 21-Day Schedule in Patients with Advanced Cancer

Keith T. Flaherty, Patricia LoRusso, Angela DeMichele et al. · Clinical Cancer Research · 2011 · 361 citations

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A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells

Hui Li, Jinglan Wang, Gil Mor et al. · Science · 2008 · 319 citations

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