Kyle Gowen

Activation of MET via Diverse Exon 14 Splicing Alterations Occurs in Multiple Tumor Types and Confers Clinical Sensitivity to MET Inhibitors

Garrett M. Frampton, Siraj M. Ali, Mark R. Rosenzweig et al. · Cancer Discovery · 2015 · 796 citations · Full text

Medicine, Molecular Genetics, Oncology +16

Impact of <i>EML4-ALK</i> Variant on Resistance Mechanisms and Clinical Outcomes in <i>ALK</i>-Positive Lung Cancer

Viola W. Zhu, Satoshi Yoda, Beow Y. Yeap et al. · Journal of Clinical Oncology · 2018 · 337 citations · Full text

Medicine, Oncology, Pharmacology +17

Beyond microsatellite testing: assessment of tumor mutational burden identifies subsets of colorectal cancer who may respond to immune checkpoint inhibition

David Fabrizio, Thomas J. George, Richard F. Dunne et al. · Journal of Gastrointestinal Oncology · 2018 · 271 citations · Full text

Medicine, Immunology, Oncology +17

A Novel Next-Generation Sequencing Approach to Detecting Microsatellite Instability and Pan-Tumor Characterization of 1000 Microsatellite Instability–High Cases in 67,000 Patient Samples

Sally E. Trabucco, Kyle Gowen, Sophia L. Maund et al. · Journal of Molecular Diagnostics · 2019 · 225 citations · Full text

Medicine, Molecular Genetics, Oncology +17

Total mutation burden (TMB) in lung cancer (LC) and relationship with response to PD-1/PD-L1 targeted therapies.

David R. Spigel, Alexa B. Schrock, David Fabrizio et al. · Journal of Clinical Oncology · 2016 · 180 citations

Medicine, Molecular Genetics, Oncology +17