Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity

Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1

Akira Kobayashi, Moon-Il Kang, Yoriko Watai et al. · Molecular and Cellular Biology · 2005 · 930 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

Jung H. Suh, Swapna V. Shenvi, Brian Dixon et al. · Proceedings of the National Academy of Sciences · 2004 · 770 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

Dong‐Mei Ren, Nicole Villeneuve, Tao Jiang et al. · Proceedings of the National Academy of Sciences · 2011 · 652 citations

Medicine, Oncology, Pharmacology +14

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

Christopher J. Harvey, Rajesh K. Thimmulappa, Anju Singh et al. · Free Radical Biology and Medicine · 2008 · 528 citations

Life Sciences, Biochemistry, Cell Biology +16

Altered Glutathione Redox State in Schizophrenia

Jeffrey Yao, Sherry Leonard, Ravinder Reddy · Disease Markers · 2006 · 321 citations · Full text

Life Sciences, Neuroscience, Psychiatry +17