Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Jean‐Philippe Coppé · 2008 · 4.1K citations · Full text

Medicine, Cell Biology, Oncology +16

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

Kıvanç Birsoy, Walter W. Chen, Elizaveta Freinkman et al. · Cell · 2015 · 1.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12

Programmed Cell Senescence during Mammalian Embryonic Development

Daniel Muñoz‐Espín, Marta Cañamero, Antonio Maraver et al. · Cell · 2013 · 1.4K citations · Full text

Life Sciences, Cell Biology, Developmental Biology +11

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

Christopher D. Wiley, Michael C. Velarde, Pacôme Lecot et al. · Cell Metabolism · 2015 · 1.2K citations · Full text

Life Sciences, Biology, Cell Biology +10

Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence

Werner Zwerschke, Sybille Mazurek, Petra Stöckl et al. · Biochemical Journal · 2003 · 252 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17