Concepedia

Electron Transport Chain Dysfunction

Electron Transport Chain Dysfunction is a pathological impairment in the mitochondrial electron transport chain—a series of protein complexes responsible for oxidative phosphorylation—characterized by disrupted electron flow, reduced ATP production, and increased reactive oxygen species generation, leading to cellular energy deficit and metabolic dysregulation.

545

Publications

48.7K

Citations

3.4K

Authors

958

Institutions

Publications per year

2017–2026

179

Variants

Mitochondrial Respiratory Chain Dysfunction

Parents

Publications

545

Characterization of the Cellular Reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): Subcellular Localization, Substrate Dependence, and Involvement of Mitochondrial Electron Transport in MTT Reduction

Michael V. Berridge, An S. Tan · Archives of Biochemistry and Biophysics · 1993 · 1.4K citations

, , +15

Abnormalities of the electron transport chain in idiopathic parkinson's disease

W. Davis Parker, Sally J. Boyson, Janice K. Parks · Annals of Neurology · 1989 · 1.1K citations

, , +17

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

Jenni Durieux, Suzanne Wolff, Andrew Dillin · Cell · 2011 · 1.1K citations · Full text

, , +14

Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes

Vladimir B. Ritov, Elizabeth V. Menshikova, Jing He et al. · Diabetes · 2005 · 884 citations · Full text

, , +15

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

Carmen García‐Ruiz, Anna Colell, Albert Morales et al. · Journal of Biological Chemistry · 1997 · 807 citations · Full text

, , +16

1–5 of 545

Authors

3.4K

  1. WD
    W. Davis Parker

    University of Virginia, United States

    9 publications · 3.7K citations

    9

    h-index

  2. CL
    Charles L. Hoppel

    Case Western Reserve University, United States

    9 publications · 1.5K citations

    9

    h-index

  3. EJ
    Edward J. Lesnefsky

    Virginia Commonwealth University, United States

    9 publications · 1K citations

    9

    h-index

  4. JP
    John Papaconstantinou

    The University of Texas Medical Branch at Galveston, United States

    7 publications · 528 citations

    7

    h-index

  5. QC
    Qun Chen

    Virginia Commonwealth University, United States

    7 publications · 733 citations

    7

    h-index

1–5 of 3.4K

Institutions

958

  1. Case Western Reserve University

    Cleveland, United States

    14 h-index

    38 publications

    5.8K citations

  2. Harvard University

    Cambridge, United States

    13 h-index

    61 publications

    7.7K citations

  3. The University of Texas at San Antonio Health Science Center

    San Antonio, United States

    12 h-index

    46 publications

    2.9K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    11 h-index

    31 publications

    7.1K citations

  5. University of Washington

    Seattle, United States

    10 h-index

    34 publications

    1.4K citations

  6. The University of Texas Medical Branch at Galveston

    Galveston, United States

    10 h-index

    33 publications

    2K citations

  7. The University of Texas Southwestern Medical Center

    Dallas, United States

    10 h-index

    89 publications

    5.3K citations

  8. University of Pittsburgh

    Pittsburgh, United States

    9 h-index

    45 publications

    9.2K citations

1–8 of 958

Venues

  1. Free Radical Biology and Medicine

    20 publications · 1.6K citations

    18

    h-index

  2. PLoS ONE

    15 publications · 1.2K citations

    15

    h-index

  3. Journal of Biological Chemistry

    JBC · 15 publications · 2.5K citations

    14

    h-index

  4. PubMed

    Repository · 10 publications · 723 citations

    10

    h-index

  5. Journal of Neurochemistry

    JNC · 9 publications · 1K citations

    9

    h-index

1–5