The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

Aging: A Theory Based on Free Radical and Radiation Chemistry

Denham Harman · Journal of Gerontology · 1956 · 8.4K citations

Metabolic Rate, Dna Damage, Anti-aging +24

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

Marcella A. Calfon, Huiqing Zeng, Fumihiko Urano et al. · Nature · 2002 · 2.8K citations

Protein Secretion, Signal Transduction, Xbp-1 Mrna +12

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Irina M. Conboy, Michael J. Conboy, Amy J. Wagers et al. · Nature · 2005 · 2.2K citations

Regenerative Medicine, Lifespan Extension, Developmental Biology +13

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

Cheol‐Koo Lee, Roger G. Klopp, Richard Weindruch et al. · Science · 1999 · 1.5K citations

Anti-aging, Aging, Genetics +16

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

Matthias Blüher, Barbara B. Kahn, C. Ronald Kahn · Science · 2003 · 1.3K citations

Aging, Insulin Receptor, Caloric Restriction +16