Walter W. Chen

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Richard Possemato, Kevin M. Marks, Yoav D. Shaul et al. · Nature · 2011 · 1.7K citations · Full text

Tumor Biology, Breast Oncology, Medicine +9

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

Kıvanç Birsoy, Walter W. Chen, Elizaveta Freinkman et al. · Cell · 2015 · 1.4K citations · Full text

Biosynthesis, Essential Role, Biochemistry +9

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

Kıvanç Birsoy, Richard Possemato, Franziska K. Lorbeer et al. · Nature · 2014 · 722 citations · Full text

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

Haiyan Yu, Nicholas W. Hughes, Bingxu Liu et al. · Cell · 2017 · 664 citations · Full text

Functional Genomics, Oncogenic Ras, Synthetic Lethal Interactions +10

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Michael E. Pacold, Kyle R. Brimacombe, Sze Ham Chan et al. · Nature Chemical Biology · 2016 · 571 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Serine Synthesis +10