Nicholas W. Hughes

Identification and characterization of essential genes in the human genome

Kıvanç Birsoy, Nicholas W. Hughes, Kevin M. Krupczak et al. · Science · 2015 · 1.7K citations · Full text

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

Haiyan Yu, Nicholas W. Hughes, Bingxu Liu et al. · Cell · 2017 · 664 citations · Full text

Functional Genomics, Oncogenic Ras, Synthetic Lethal Interactions +10

dCas9-based gene editing for cleavage-free genomic knock-in of long sequences

Chengkun Wang, Yuanhao Qu, Jason Cheng et al. · Nature Cell Biology · 2022 · 73 citations · Full text

A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer

Hongchen Cai, Su Kit Chew, Chuan Li et al. · Cancer Discovery · 2021 · 61 citations · Full text

Microbial single-strand annealing proteins enable CRISPR gene-editing tools with improved knock-in efficiencies and reduced off-target effects

Chengkun Wang, Jason Cheng, Qianhe Zhang et al. · Nucleic Acids Research · 2020 · 36 citations · Full text

Reduced Off-target Effects, Engineering, Biomolecular Tool +20