Interaction between HCMV pUL83 and human AIM2 disrupts the activation of the AIM2 inflammasome

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis et al. · Nature · 2009 · 2.5K citations · Full text

Signal Transduction, Natural Sciences, Cell Interaction +12

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

Tatsuya Saitoh, Naonobu Fujita, Myoung Ho Jang et al. · Nature · 2008 · 2K citations

Inflammation, Cytokine, Cell Autophagy +7

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Teresa Fernandes‐Alnemri, Je‐Wook Yu, Pinaki Datta et al. · Nature · 2009 · 1.8K citations · Full text

Signal Transduction, Cell Regulation, Cell Interaction +6

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

Chong-Shan Shi, Kevin Shenderov, Ning-Na Huang et al. · Nature Immunology · 2012 · 1.3K citations · Full text

Immunology, Immune Regulation, Cell Death +17

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

Alvin Lu, Venkat Giri Magupalli, Jianbin Ruan et al. · Cell · 2014 · 1.3K citations · Full text

Engineering, Self-assembly, Polymer Science +3