Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and function

Metabolite profiles and the risk of developing diabetes

Thomas J. Wang, Martin G. Larson, Ramachandran S. Vasan et al. · Nature Medicine · 2011 · 3.1K citations · Full text

Life Sciences, Biochemistry, Endocrinology +12

Human gut microbes impact host serum metabolome and insulin sensitivity

Helle Pedersen, Valborg Guðmundsdóttir, Henrik Bjørn Nielsen et al. · Nature · 2016 · 2.1K citations · Full text

Life Sciences, Microbiology, Physiology +16

Sestrin2 is a leucine sensor for the mTORC1 pathway

Rachel L. Wolfson, Lynne Chantranupong, Robert A. Saxton et al. · Science · 2015 · 1.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

Hyunseok Kim, Krish Patel, Kristi Muldoon‐Jacobs et al. · Cancer Cell · 2010 · 795 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +14

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

Jared R. Mayers, Chen Wu, Clary B. Clish et al. · Nature Medicine · 2014 · 662 citations · Full text

Medicine, Cancer Biology, Oncology +12