Concepedia

Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro – in vivo extrapolation of hepatic clearance

Veera Raghava Chowdary Palacharla, Venkatesham Uthukam, Arunkumar Manoharan, Ranjith Kumar Ponnamaneni, Nagasurya Prakash Padala, Rajesh Kumar Boggavarapu, Gopinadh Bhyrapuneni, Devender Reddy Ajjala, Ramakrishna Nirogi

European Journal of Pharmaceutical Sciences · 2017 · 15 citations · 22 references

DOI

Concepts

References

22

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

, , +17

In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model

J. Brian Houston, Kathryn E. Kenworthy · Drug Metabolism and Disposition · 2000 · 392 citations

, , +17

Structure of Human Microsomal Cytochrome P450 2C8

G. Schoch, Jason K. Yano, Michael R. Wester et al. · Journal of Biological Chemistry · 2004 · 381 citations · Full text

, , +17

Amodiaquine Clearance and Its Metabolism to N-Desethylamodiaquine Is Mediated by CYP2C8: A New High Affinity and Turnover Enzyme-Specific Probe Substrate

Xueqing Li, Anders Björkman, Tommy B. Andersson et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 285 citations

, , +17

The “Albumin Effect” and Drug Glucuronidation: Bovine Serum Albumin and Fatty Acid-Free Human Serum Albumin Enhance the Glucuronidation of UDP-Glucuronosyltransferase (UGT) 1A9 Substrates but Not UGT1A1 and UGT1A6 Activities

Andrew Rowland, Kathleen Knights, Peter I. Mackenzie et al. · Drug Metabolism and Disposition · 2008 · 181 citations

, , +12