Blood · 2017 · 109 citations · 39 references
Life SciencesCell BiologyMolecular BiologyCancer ImmunologyMolecular OncologyTumor ImmunologyBone Marrow MicroenvironmentBone Marrow PhysiologyMultiple MyelomaMyeloid-derived Suppressor CellsTumor-associated MacrophagesTumor-stroma InteractionsMcl-1 FunctionMultiple Myeloma TherapyMyeloid-derived Suppressor Cell CytokinesMyeloid-derived Suppressor Cell ModulationMyeloid-derived Suppressor Cell Signaling PathwaysMyeloid-derived Suppressor Cell SurvivalMyeloma Pathogenesis
Key Points Bone marrow stromal cell–derived IL-6 induces Mcl-1 dependence through transcriptional and posttranslational changes in the Bcl-2 family. Blocking IL-6 signaling pathways sensitizes myeloma to inhibitors of Bcl-2 and Bcl-2/Bcl-xL.
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A family of cytokine-inducible inhibitors of signalling
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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL
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The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
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Medicine, Oncology, Pharmacology +11