Metformin inhibits the proliferation of human prostate cancer PC-3 cells via the downregulation of insulin-like growth factor 1 receptor

Metformin and reduced risk of cancer in diabetic patients

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Public Health, Health Sciences, Infectious Diseases +14

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap · Biochemical Journal · 2000 · 2.1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

Issam Ben Sahra, Kathiane Laurent, Agnès Loubat et al. · Oncogene · 2008 · 853 citations

Medicine, Endocrinology, Pharmacology +11

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

Sujata Persad, Sarah Attwell, Virginia Gray et al. · Proceedings of the National Academy of Sciences · 2000 · 433 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Accumulation of metformin by tissues of the normal and diabetic mouse

Carol Wilcock, Clifford J. Bailey · Xenobiotica · 1994 · 414 citations

Pharmacy, Pharmacokinetics, Pharmacology +7