The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

Issam Ben Sahra, Kathiane Laurent, Agnès Loubat, +6

Oncogene

Cyclin D1 LevelAntidiabetic Drug MetforminAntitumoral EffectDiabetes ManagementInsulin Management +6

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

Isaam Ben Sahra, Claire Regazzetti, Guillaume Robert, +6

Cancer Research

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

Issam Ben Sahra, Kathiane Laurent, Sandy Giuliano, +11

Cancer Research

Chemoprevention StrategyApoptosisCancer Cell MetabolismCell DeathProstate Cancer Cells +14

Inhibition of p38MAPK Increases Adipogenesis From Embryonic to Adult Stages

Myriam Aouadi, Kathiane Laurent, Matthieu Prot, +3

Diabetes

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

Issam Ben‐Sahra, Béatrice Dirat, Kathiane Laurent, +5

Cell Death and Differentiation

InflammationReductive StressSignal TransductionSignaling PathwayCell Regulation +9

p38 Mitogen‐Activated Protein Kinase Activity Commits Embryonic Stem Cells to Either Neurogenesis or Cardiomyogenesis

Myriam Aouadi, Frédéric Bost, Leslie Caron, +3

Stem Cells

p38MAP Kinase activity is required for human primary adipocyte differentiation

Myriam Aouadi, Jennifer Jager, Kathiane Laurent, +6

FEBS Letters

Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity

Jennifer Jager, V. Corcelle, Thierry Grémeaux, +8

Diabetologia

Insulin ResistanceObesityMetabolic SyndromeLeptin-deficient MiceMolecular Physiology +12

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

Camille Loubière, Stéphan Clavel, Jérôme Gilleron, +19

Scientific Reports

Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells

Camille Loubière, Thomas Goiran, Kathiane Laurent, +3

Oncotarget