Neuropharmacology · 2017 · 22 citations · 30 references
MedicineMedicinal ChemistryPharmacologyDrug DiscoveryMolecular PharmacologyStructural BiologyDrug-receptor InteractionsLigand BindingMolecular DockingProtein-ligand BindingReceptor PharmacologyReceptor-ligand InteractionsChemical Structure-activity RelationshipsCrystallographic ModelingLigand Binding AffinityLigand Orientation EffectsOrientationsOrthosteric Binding SitesOrthosteric InteractionsReceptor-ligand Structural Biology
receptor binding site. Our results show that even quite structurally similar molecules can adopt different orientations in the same binding site, and that caution may be needed when using homologous proteins to predict ligand binding.
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X-ray structure of the mouse serotonin 5-HT3 receptor
Ghérici Hassaı̈ne, Cédric Deluz, Luigino Grasso et al. · Nature · 2014 · 377 citations · Full text
Strong hydrophobic nature of cysteine residues in proteins
Nozomi Nagano, Motonori Ota, Ken Nishikawa · FEBS Letters · 1999 · 171 citations · Full text