Concepedia

Orthosteric Interactions

Orthosteric Interactions is the binding of a ligand to the primary active site of a receptor or enzyme, thereby directly competing with the endogenous agonist or substrate for occupancy of the functional site.

258

Publications

11.1K

Citations

1.6K

Authors

463

Institutions

Publications per year

2017–2026

132

Parents

Publications

258

Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol‐dimethylheptyl at the type 1 and type 2 cannabinoid receptors

Mylyne Tham, Orhan Yılmaz, Mariam Alaverdashvili et al. · British Journal of Pharmacology · 2018 · 315 citations · Full text

, , +17

Discovery of 1,2,4-Triazine Derivatives as Adenosine A<sub>2A</sub> Antagonists using Structure Based Drug Design

Miles Congreve, Stephen P. Andrews, A.S. Dore et al. · Journal of Medicinal Chemistry · 2012 · 304 citations · Full text

, , +14

An orthosteric inhibitor of the Ras-Sos interaction

Anupam Patgiri, Kamlesh Yadav, Paramjit S. Arora et al. · Nature Chemical Biology · 2011 · 294 citations

, , +14

Structural mechanism of ligand activation in human calcium-sensing receptor

Yong Geng, Lidia Mosyak, Igor Kurinov et al. · eLife · 2016 · 263 citations · Full text

, , +17

Allosite: a method for predicting allosteric sites

Wenkang Huang, Shaoyong Lu, Zhimin Huang et al. · Bioinformatics · 2013 · 226 citations · Full text

, , +17

1–5 of 258

Authors

1.6K

  1. AC
    Arthur Christopoulos

    Monash University, Australia

    16 publications · 775 citations

    14

    h-index

  2. PM
    Patrick M. Sexton

    Monash University, Australia

    10 publications · 623 citations

    10

    h-index

  3. PJ
    Peter J. Scammells

    Monash University, Australia

    7 publications · 338 citations

    7

    h-index

  4. FA
    Francine Acher

    Centre National de la Recherche Scientifique, France

    7 publications · 251 citations

    7

    h-index

  5. CJ
    Christopher J. Langmead

    Monash University, Australia

    6 publications · 550 citations

    6

    h-index

1–5 of 1.6K

Institutions

463

  1. Monash University

    Melbourne, Australia

    19 h-index

    97 publications

    4.3K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    77 publications

    3.1K citations

  3. Discovery Institute

    Seattle, United States

    11 h-index

    48 publications

    1.4K citations

  4. Inserm

    Paris, France

    10 h-index

    41 publications

    2.4K citations

  5. National Institutes of Health

    Bethesda, United States

    9 h-index

    48 publications

    1.8K citations

  6. University of Copenhagen

    Copenhagen, Denmark

    9 h-index

    69 publications

    2K citations

  7. University of Bonn

    Bonn, Germany

    8 h-index

    30 publications

    1.3K citations

  8. University of Glasgow

    Glasgow, United Kingdom

    7 h-index

    34 publications

    2.1K citations

1–8 of 463

Venues

  1. Journal of Medicinal Chemistry

    22 publications · 1.2K citations

    18

    h-index

  2. Molecular Pharmacology

    22 publications · 1.1K citations

    18

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 10 publications · 582 citations

    10

    h-index

  4. Journal of Chemical Information and Modeling

    JCIM · 9 publications · 204 citations

    9

    h-index

  5. Journal of Biological Chemistry

    JBC · 9 publications · 780 citations

    9

    h-index

1–5