The BET bromodomain inhibitor JQ1 radiosensitizes non-small cell lung cancer cells by upregulating p21

Cancer treatment and survivorship statistics, 2016

Kimberly D. Miller, Rebecca L. Siegel, Chun Chieh Lin et al. · CA A Cancer Journal for Clinicians · 2016 · 6.2K citations · Full text

Medicine, Oncology, Population Health Sciences +17

Selective inhibition of BET bromodomains

P. Filippakopoulos, Jun Qi, S. Picaud et al. · Nature · 2010 · 4.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +5

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake Delmore, Ghayas C. Issa, Madeleine E. Lemieux et al. · Cell · 2011 · 2.8K citations · Full text

Medicine, Cancer Biology, Molecular Biology +10

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Johannes Zuber, Junwei Shi, Eric Wang et al. · Nature · 2011 · 1.9K citations

Life Sciences, Molecular Biology, Molecular Genetics +9

Targeting MYC dependence in cancer by inhibiting BET bromodomains

Jennifer A. Mertz, Andrew R. Conery, Barbara M. Bryant et al. · Proceedings of the National Academy of Sciences · 2011 · 1.1K citations · Full text

Life Sciences, Molecular Biology, Oncology +17